The structure of vacidin A, an aromatic heptaene macrolide antibiotic. I. Complete assignment of the 1H NMR spectrum and geometry of the polyene chromophore.

نویسندگان

  • P Sowiński
  • P Gariboldi
  • A Czerwiński
  • E Borowski
چکیده

The constitution of vacidin A, a representative of the aromatic heptaene macrolide antibiotics was established on the basis of 13C and 1H-1H double quantum filtered correlated spectroscopy, rotating frame nuclear Overhauser effect spectroscopy, J-resolved 1H as well as 1H-13C correlation NMR spectra. Geometry of the polyene chromophore was determined as 22E,24E,26E,28Z,30Z,32E,34E.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 42 11  شماره 

صفحات  -

تاریخ انتشار 1989